帕齐阴谋San Gimignano. The Pazzi family members, Jacopo, Francesco, and Vieri, met with Rodrigo Borgia. The group discussed their plan to overthrow the Medici dynasty, and to instate the Templars as the government of the city.
Francesco himself was tasked with organizing the Templar forces in Florence, and then sending word to his fellow conspirators when the time came to carry out the plans. However, after the meeting ended, Vieri remained in the city. Mario Auditore was aware of this, so he informed Ezio, and the two led an attack on the city. Mario led the mercenaries into the city, while Ezio made his way to Vieri, and assassinated him.
Later that year, Francesco met with another group of Templars in Florence in the catacombs under Santa Maria Novella. The group, Francesco, Jacopo, Rodrigo, Bernardo Baroncelli, and Stefano da Bagnone, talked about finalizing their plans to gain control of Florence and overthrow the Medici. The group joked about the Medici's arrogance and stupidity, but ensured Rodrigo that the plans would be carried out successfully. Once their discussion had finished, Rodrigo claimed that a new sun would rise over Florence the next morning, before leaving for Rome.
As planned, during high mass the next morning at the Duomo, Francesco and his co-conspirators attacked the Medici family. Francesco and Bernardo charged at Giuliano de' Medici, and stabbed him multiple times, killing him. Stefano also stabbed Lorenzo de' Medici, however he only was able to injure Lorenzo, as the Assassin Ezio Auditore entered the battle. Ezio fought off Francesco and his men, successfully defending Lorenzo. Francesco fled, and Ezio escorted Lorenzo back to his home to receive medical treatment.
- “You again? Why aren't you dead? Men! Slaughter him!”
- ——Francesco upon seeing Ezio on the rooftops.[来源]
Ezio followed Francesco over the rampart, and began chasing him through the Florentine streets. Ezio eventually caught up to Francesco though, and assassinated him. In his final words, Francesco merely claimed that everything was over with the failure of their conspiracy.
Later, Francesco's body was hung from the top of the Palazzo della Signoria by Medici supporters, which frightened Jacopo de' Pazzi, and caused him to flee from the city, knowing that their plans had failed.
He was also confident and had much pride in himself and his fellow conspirators, claiming the Medici were too arrogant and too stupid to notice the plans being made against them. Francesco backed up this confidence by claiming to Rodrigo that no mistakes would be made in their plans.
Francesco was also violent and sadistic, stabbing Giuliano de' Medici multiple times after he was dead whilst yelling madly, demonstrating his desire to kill. Despite his violent behavior however, he fled when confronted by Ezio Auditore, and chose to run from the Assassin, rather than stay and fight.
There is also a hint that Francesco often ignored his son, Vieri, either intentional or not. It is stated in the letter from Fra Giocondo that Vieri often acted brashly and competed in competitions he had rigged in his favor merely to gain Francesco's attentions, hoping to win his approval. Francesco also seemed to show little remorse after his son's death, further suggesting that their relationship was not a strong one.
- Ezio: Now Firenze will judge you for what you've done.
- Francesco: It's over... It's all over...
- Ezio: Meglio essere felici in questa vita che aspirare a esserlo nella prossima. (Better to be content in this life, than aspire to it in the next) Requiescat in pace. (Rest in peace.)
- 真实历史上,弗朗切斯科·德·帕齐被提到在疯狂地刺杀朱利亚诺·德·美地奇时不小心刺伤了自己的大腿. 尽管刺客信条 II中这一幕并未出现 , 他却在改编小说, 文艺复兴.中犯下了这个错误
- 与埃齐奥对峙时, 弗朗切斯科从领主宫楼顶跳入一个干草堆以求快速逃生. 他和刺客信条III中海瑟姆·肯维以及康纳的母亲是目前仅有的已知几个不是刺客而能跳出某种形式的信仰之跃的人. 
- 他和他的儿子在刺客信条：兄弟会 中一段被抑制的记忆里被短暂提及.
- 在刺客信条:启示录 中的记忆片段The Prince's Banquet中, 埃齐奥在伪装成行吟诗人时歌唱了维耶里和弗朗切斯科的死亡.